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Vital Signs
Investigator Insight
In this section, we highlight the human side of biomedical investigation, putting a few questions to a researcher at DMS-DHMC.
Brent Berwin, Ph.D.
Assistant Professor of Microbiology and Immunology
Berwin studies how white blood cells induce immune responses—in particular, how molecular chaperones (molecules that help proteins fold) activate the immune system, how white blood cells clear bacteria after an infection, and how immune cells induce antitumor responses. He joined the faculty in 2004.
What are the keys to being a successful scientist?
Work hard. Plan well. Think things through.
And be in an environment where you enjoy
working and spending time.
What got you interested in science?
I've always enjoyed science, although for a long
time I thought I'd end up working for the Oregon
Department of Fish and Wildlife (which I
did for a couple of summers). Then I came back
from my senior year of college abroad, needed a
job, and got sucked into working in a virology
lab for two years—that was the beginning
of the end.
Are there any
misconceptions people
have about your field?
Lots. Most people
outside of science
don't really understand
what we do
from day to day.
And it's always vaguely entertaining when a random
person asks me about some obscure disease
or condition they have, fully expecting me to
have a working knowledge of the entire therapeutic
and medical field.
What's a typical day like for you?
After getting to the lab, I try to get any long or
continuing experiments under way; check the
baseball box scores and

make sure my fantasy baseball team is doing okay (or not); search for recent published papers that are relevant to our work; check on our cell cultures and our mice; go back down to the animal facility and do what I forgot to do the first time; and check in with the lab members to see what they are doing, how things are going, and how we can press forward. On top of all that, I am usually writing grants and manuscripts or attending meetings.
What were your first paying jobs?
In high school, I had the usual array of restaurant
jobs—busting suds. In college, I worked in
the chemistry department stockroom and, during
the summers, for the Oregon Department of
Fish and Wildlife doing a census of salmon
and squawfish in the McNary Reservoir on the Columbia River in Oregon. And for two years before going to grad school, I was a technician at Oregon Health and Science University.
What are your favorite nonwork activities?
Pretty much anything outside: hiking, biking,
running, swimming, canoeing, etc. I think it's
important to engage in activities outside the lab
to get the blood flowing, work off frustrations,
and maintain sanity.
What place would you most like to travel to?
There are not many places I wouldn't want to
explore—in times of peace. I love traveling. I
visited a lot of places on an around-the-world
trip after graduate school. I think my credit card
is still recovering from that.
Do you always have a working hypothesis in the lab?
If you consider "let's try this and see what happens"
a working hypothesis, then yes, we do.
What do you like most about your job?
The people I work with and around—what a
good group of intelligent, entertaining, and motivated
people. I'm proud that our lab members
enjoy each other's company and can work, play,
and (usually) laugh together. I also feel pretty
lucky to have a job where I get paid to do something
I enjoy. That said, my department chair
jokes that I'm lucky to have a job at all.
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