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Discoveries
Research Briefs
Identifying drugflation
The economy is not the only thing that's inflated.
People with inflammatory bowel disease
(IBD) overestimate the effectiveness—and underestimate the dangers—of the commonly
used drug infliximab (sold as Remicade).
So found a team of Dartmouth
and Harvard researchers in a survey of
165 patients or parents of patients.
When asked about a hypothetical drug
that mirrored the benefits and risks of infliximab,
a majority of respondents said they
would not take the drug. "It is likely that
marketing plays some role in both patients'
and physicians' beliefs," the authors wrote in
the journal Inflammatory Bowel Diseases.
An expressive manner
A member of a common molecular family is
one of the culprits behind the growth and
metastasis of pancreatic cancer, according to
a Dartmouth-led study in the Journal of Clinical
Investigation. GPC1, as it is known, is
overexpressed in pancreatic cancer, reported
a team led by Murray Korc,
M.D., "and attenuation of GPC1
expression dampens [the response to growth
factors] and slows pancreatic tumor growth.
. . . Taken together, the present findings suggest
that targeting GPC1 may ultimately
yield novel therapeutic options" for treating
pancreatic cancer and its metastases.
Staying abreast of the news
Magnetic resonance imaging (MRI) just isn't
worth it as a breast-cancer screening tool for
women who have already had a lumpectomy
and radiation therapy. That's the conclusion
of Dartmouth researchers from the Departments
of Surgery and Radiology. After
analyzing the records of 471 women
who received standard care, they estimated
that the total cost of using annual
MRIs to detect recurrences would have been
more than $7 million. "A total of 2,570MRIs
would have been performed," they wrote in
the Annals of Surgical Oncology, "but these
would have been unlikely to change the therapy
or survival of any of our patients."
A big-hearted mouse
When the Grinch's heart grew three sizes in
one day, he must have grown a lot of new
blood vessels, too—at least according to a recent
finding made by the lab of DMS's
Michael Simons,M.D. By manipulating a
gene in a mouse, the researchers discovered
that vessel density controls organ
size. "An increase in the size of the
vascular bed in the normal heart," wrote Simons
and his coauthors in the Journal of Clinical
Investigation, "leads to increased cardiac
mass and . . . increased cardiac performance."
In other words, more blood vessels result in
a larger—and more powerful—heart.
Air line guide
An increasingly popular way to deliver oxygen
to infants with respiratory problems may
be easier but should not replace the standard
method, DMS researchers recently reported
in Pediatrics. The team measured the pressure
inside the mouths of 27 infants as they received
oxygen through heated,
humidified, high-flow nasal cannula
therapy. "Only in the smallest
infants with the highest flow rates, with
the mouth fully closed, can clinically significant
but unpredictable levels of continuous
positive airway pressure be achieved," wrote
Zuzanna Kubicka, M.D., and her coauthors.
"Our results and those of others also raise important
safety and monitoring issues."
Air line guide
Despite efforts to ensure equal access to organs,
country-dwellers are up to 20% less
likely than their urban counterparts to get a
heart, liver, or kidney transplant, concluded
a study led by DMS surgeon David
Axelrod, M.D. Patients in "rural regions
and small towns face multiple
barriers to health-care access," wrote
Axelrod and his coauthors in the Journal of
the American Medical Association, "including
the need to travel long distances, the lack of
locally available specialty services, and difficulty
in receiving follow-up care."
Depression is prevalent among teens seeking care in the ER, but they're rarely screened for it. A DMS study showed a two-question screen is nearly as sensitive as a 20-question tool.
Another study from SPORT found that patients who had a diskectomy saw an improvement not only in back pain, but also in leg pain; in fact, their leg pain declined more.
DMS's David Goodman, M.D., found a 200% difference in physician supply across the U.S. For every physician who has moved to a lowsupply area, four moved to a high-supply area.
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