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DISCOVERIES
Research Briefs
A no-brainer
Heart bypass surgery, in rare cases, can lead to
brain injury, but a recent study from DMS
and Maine Medical Center suggests a way to
reduce the risk. In a small study, the researchers
found that papaverine—a drug
commonly used during bypass surgery
to improve blood flow—was more effective
when applied topically to a vessel
than when injected into a vessel. Signals
indicating reduced blood flow to the brain
were observed in seven of 12 patients who
were injected with papaverine versus none
of 28 who received the drug topically.
Real-world result
A common treatment for post-traumatic
stress disorder (PTSD) doesn't produce the
same result in the real world as it does in randomized
controlled trials. DMS researcher
Claudia Zayfert, Ph.D., and colleagues observed
that only 28% of patients undergoing
cognitive behavioral therapy for PTSD
finished their treatment, whereas
73% of patients in randomized
controlled trials did. The completion
rate, they observed in the Journal
of Traumatic Stress, "although disturbingly
low, was better than expected." And since
research definitions of completion differ from
clinical definitions, they say, the gap between
the studies may not be quite so large.
Performance indicators
Senior citizens usually don't consult hospital
performance data when deciding where to
have surgery. So found a survey of Medicare
patients by researchers at the DMS-affiliated
VA Medical Center. Most of those surveyed
"relied primarily on the opinions
of their referring physician or
family and friends in choosing where to
have surgery," wrote Lisa Schwartz, M.D.,
and colleagues in the British Medical Journal.
Many said they'd switch hospitals based on
mortality data, but since they rely on their
physician's opinion, the researchers argued
that "performance data should be directed at
referring physicians," not patients.
Calculating cancer's effect
It's no surprise to learn that breast cancer patients
experience mental and emotional distress.
A study by DHMC's Comprehensive
Breast Program revealed just how common
psychological disturbances are among women
with early-stage breast cancer.
"We found that 46% of the 185
women that we screened . . . meet or
exceed our established thresholds for mental
health intervention," said Caroline Moore,
M.P.H., at a recent breast cancer symposium
in Texas. About 42% of the women had high
stress levels, almost 11% were depressed, and
about 9% showed signs of clinical anxiety.
Surgical advice
Between one-third and two-thirds of patients
undergoing gastric bypass surgery—a treatment
for severe obesity—develop gallstones.
A study by DMS surgeon Brent White, M.D.,
found that the most cost-effective
ways to prevent them are removing the
gallbladder at the time of the bypass and
treating the patient with the drug ursodiol
for six months after surgery. "Surgeons
. . . should consider either using ursodiol or
performing a concurrent cholecystectomy,"
White advised at the annual meeting of the
American College of Surgeons.
Fungal finding
A class of deadly fungal infections called
Zygomycoses was the subject of a paper by
Jack Brown, Pharm.D. "Zygomycosis appears
to have become more common since the
mid-1990s," he wrote in the American Journal
of Health-System Pharmacy, "and has been
identified in up to 6.8% of patients at autopsy."
Brown summarized the taxonomy,
epidemiology, pathogenesis,
diagnosis, and treatment
of these dangerous fungi. Patients at
the highest risk of infection, he reported, are
diabetics, intravenous drug abusers, premature
infants, recipients of bone marrow transplants,
and those who get certain therapies to
remove excess iron from the body.
In a study of 1,500 patients, DMS gastroenterologist Douglas Robertson, M.D., found that those with diets high in processed meats had a higher risk of developing precancerous colon polyps.
A randomized, controlled trial led by DMS's Allen Dietrich, M.D., showed that a series of phone calls can significantly improve cancer screening rates among low-income women.
Two Dartmouth researchers mapped anatomical changes in the brains of college freshmen and determined that the brain's structure continues to change significantly after age 18.
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